Serratia marcescens colonies on BTB agar medium. PHOTO: UNSPLASH
A closer look at how machine intelligence is helping doctors see cancer in an entirely new light.
Updated
November 28, 2025 4:18 PM
Serratia marcescens colonies on BTB agar medium. PHOTO: UNSPLASH
Artificial intelligence is beginning to change how scientists understand cancer at the cellular level. In a new collaboration, Bio-Techne Corporation, a global life sciences tools provider, and Nucleai, an AI company specializing in spatial biology for precision medicine, have unveiled data from the SECOMBIT clinical trial that could reshape how doctors predict cancer treatment outcomes. The results, presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting, highlight how AI-powered analysis of tumor environments can reveal which patients are more likely to benefit from specific therapies.
Led in collaboration with Professor Paolo Ascierto of the University of Napoli Federico II and Istituto Nazionale Tumori IRCCS Fondazione Pascale, the study explores how spatial biology — the science of mapping where and how cells interact within tissue — can uncover subtle immune behaviors linked to survival in melanoma patients.
Using Bio-Techne’s COMET platform and a 28-plex multiplex immunofluorescence panel, researchers analyzed 42 pre-treatment biopsies from patients with metastatic melanoma, an advanced stage of skin cancer. Nucleai’s multimodal AI platform integrated these imaging results with pathology and clinical data to trace patterns of immune cell interactions inside tumors.
The findings revealed that therapy sequencing significantly influences immune activity and patient outcomes. Patients who received targeted therapy followed by immunotherapy showed stronger immune activation, marked by higher levels of PD-L1+ CD8 T-cells and ICOS+ CD4 T-cells. Those who began with immunotherapy benefited most when PD-1+ CD8 T-cells engaged closely with PD-L1+ CD4 T-cells along the tumor’s invasive edge. Meanwhile, in patients alternating between targeted and immune treatments, beneficial antigen-presenting cell (APC) and T-cell interactions appeared near tumor margins, whereas macrophage activity in the outer tumor environment pointed to poorer prognosis.
“This study exemplifies how our innovative spatial imaging and analysis workflow can be applied broadly to clinical research to ultimately transform clinical decision-making in immuno-oncology”, said Matt McManus, President of the Diagnostics and Spatial Biology Segment at Bio-Techne.
The collaboration between the two companies underscores how AI and high-plex imaging together can help decode complex biological systems. As Avi Veidman, CEO of Nucleai, explained, “Our multimodal spatial operating system enables integration of high-plex imaging, data and clinical information to identify predictive biomarkers in clinical settings. This collaboration shows how precision medicine products can become more accurate, explainable and differentiated when powered by high-plex spatial proteomics – not limited by low-plex or H&E data alone”.
Dr. Ascierto described the SECOMBIT trial as “a milestone in demonstrating the possible predictive power of spatial biomarkers in patients enrolled in a clinical study”.
The study’s broader message is clear: understanding where immune cells are and how they interact inside a tumor could become just as important as knowing what they are. As AI continues to map these microscopic landscapes, oncology may move closer to genuinely personalized treatment — one patient, and one immune network, at a time.
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Tencent’s latest solution simplifies cross-border payments for Weixin users and merchants.
Updated
November 28, 2025 4:18 PM
Tencent's large penguin statue in front of a building. PHOTO: UNSPLASH
In a world where digital borders are fading faster than ever, Tencent is betting on familiarity. With the launch of TenPay Global Checkout, the company wants to make paying across countries feel as seamless as paying at home.
The new service, unveiled today, allows Weixin Mini Program merchants outside mainland China to accept a variety of local payment methods. That includes digital wallets, real-time payment networks and credit and debit cards, all through a single integration. The launch starts in Singapore and Macao SAR, where merchants can now take payments via PayNow, BOCPAY(MO), and major cards. Japan, Australia and New Zealand are next, with more regions to follow soon.
This rollout builds on the growing reach of Weixin Mini Programs, known internationally through WeChat. These small apps are built right into the platform, letting users' shop, book services and make payments without downloading separate apps. Today, there are over one million monthly active users in key overseas markets, with Mini Programs available across 92 countries and regions.
Yet, for many users abroad, paying within Mini Programs hasn’t always been simple. Foreign card restrictions, currency conversions and limited local options often made checkout a frustrating step. TenPay Global Checkout aims to change that.
“TenPay Global Checkout marks an important step in enhancing the local consumer experience. By enabling overseas Weixin Mini Program merchants to accept trusted and diversified local payment methods through one unified solution, users benefit from a more convenient and efficient payment experience. This helps merchants improve payment conversion rates, expand their user base and scale their businesses to serve a broader range of customers”, said Wenhui Yang, CEO of TenPay Global (Singapore).
What makes this move interesting isn’t just its technical simplicity—it’s the cultural bridge it builds. For users in Singapore or Japan, paying with PayNow or a local card inside Weixin feels less like an international transaction and more like an everyday purchase.
For merchants, it’s an invitation into a market that values convenience and trust. Payment familiarity, after all, often decides whether a user completes a purchase or abandons it at checkout.
The company remains focused on creating secure, connected and user-friendly payment experiences that help merchants grow and allow consumers to pay with confidence, wherever they are.
If successful, TenPay Global Checkout could quietly redefine how cross-border commerce feels—not like a transaction across regions, but a familiar tap, scan or click. In an increasingly global marketplace, that kind of familiarity might just be the next frontier in digital trust.