Serratia marcescens colonies on BTB agar medium. PHOTO: UNSPLASH
A closer look at how machine intelligence is helping doctors see cancer in an entirely new light.
Updated
November 28, 2025 4:18 PM
Serratia marcescens colonies on BTB agar medium. PHOTO: UNSPLASH
Artificial intelligence is beginning to change how scientists understand cancer at the cellular level. In a new collaboration, Bio-Techne Corporation, a global life sciences tools provider, and Nucleai, an AI company specializing in spatial biology for precision medicine, have unveiled data from the SECOMBIT clinical trial that could reshape how doctors predict cancer treatment outcomes. The results, presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting, highlight how AI-powered analysis of tumor environments can reveal which patients are more likely to benefit from specific therapies.
Led in collaboration with Professor Paolo Ascierto of the University of Napoli Federico II and Istituto Nazionale Tumori IRCCS Fondazione Pascale, the study explores how spatial biology — the science of mapping where and how cells interact within tissue — can uncover subtle immune behaviors linked to survival in melanoma patients.
Using Bio-Techne’s COMET platform and a 28-plex multiplex immunofluorescence panel, researchers analyzed 42 pre-treatment biopsies from patients with metastatic melanoma, an advanced stage of skin cancer. Nucleai’s multimodal AI platform integrated these imaging results with pathology and clinical data to trace patterns of immune cell interactions inside tumors.
The findings revealed that therapy sequencing significantly influences immune activity and patient outcomes. Patients who received targeted therapy followed by immunotherapy showed stronger immune activation, marked by higher levels of PD-L1+ CD8 T-cells and ICOS+ CD4 T-cells. Those who began with immunotherapy benefited most when PD-1+ CD8 T-cells engaged closely with PD-L1+ CD4 T-cells along the tumor’s invasive edge. Meanwhile, in patients alternating between targeted and immune treatments, beneficial antigen-presenting cell (APC) and T-cell interactions appeared near tumor margins, whereas macrophage activity in the outer tumor environment pointed to poorer prognosis.
“This study exemplifies how our innovative spatial imaging and analysis workflow can be applied broadly to clinical research to ultimately transform clinical decision-making in immuno-oncology”, said Matt McManus, President of the Diagnostics and Spatial Biology Segment at Bio-Techne.
The collaboration between the two companies underscores how AI and high-plex imaging together can help decode complex biological systems. As Avi Veidman, CEO of Nucleai, explained, “Our multimodal spatial operating system enables integration of high-plex imaging, data and clinical information to identify predictive biomarkers in clinical settings. This collaboration shows how precision medicine products can become more accurate, explainable and differentiated when powered by high-plex spatial proteomics – not limited by low-plex or H&E data alone”.
Dr. Ascierto described the SECOMBIT trial as “a milestone in demonstrating the possible predictive power of spatial biomarkers in patients enrolled in a clinical study”.
The study’s broader message is clear: understanding where immune cells are and how they interact inside a tumor could become just as important as knowing what they are. As AI continues to map these microscopic landscapes, oncology may move closer to genuinely personalized treatment — one patient, and one immune network, at a time.
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From AI love affairs to cosmic survival, 2026 has it all.
Updated
December 23, 2025 1:21 PM
A man in a space suit looking upon a ringed marble. PHOTO: UNSPLASH
Grab your popcorn—the 2026 sci-fi movie slate is stacked. We’re getting everything from post-apocalyptic survival films to AI thrillers, plus a big-space adventure and a fresh DC superhero story. Some films launch new worlds, others expand familiar ones, but all of them aim to leave an impression, but all of them look like the kind of movies you’ll want to talk about after the credits.
Here are five upcoming sci-fi movies to mark on your calendar.
Release Date: January 9, 2026
Director: Kate Dolan
Stars: Lily Sullivan, David Rysdahl and Claudia Doumit
If you like your sci-fi with a creepy edge, Soulm8te is very much in that lane. A spin-off from the M3GAN universe, the film follows a man grieving the loss of his wife who turns to an AI android to ease the pain. At first, it seems to help. The connection feels real, even comforting. But before long, it becomes a little too real and slips into something far more dangerous. What makes Soulm8te unsettling is how close it feels to the present. AI companions are no longer science fiction, and the film plays with that reality in a way that feels intimate rather than futuristic. Directed by Kate Dolan, the story stays on quiet unease instead of spectacle, allowing tension to build as affection turns possessive and attachment becomes dangerous. The film is produced by Allison Williams and James Wan, both closely involved in the hit horror franchise M3GAN, and their experience with technology-driven horror is clearly felt here. Fans of grounded, psychological sci-fi should keep this one on their radar.
Release Date: January 9, 2026
Director: Ric Roman Waugh
Stars: Gerard Butler, Morena Baccarin, Amber Rose Revah, Sophie Thompson, Trond Fausa Aurvåg
Back in 2020, Greenland introduced audiences to John Garrity (Gerard Butler), a father racing against time to save his family as comet fragments threatened to wipe out life on Earth. The film ended with survivors heading into bunkers deep in Greenland, hanging on to the last thin thread of hope. This sequel follows the Garrity family as they leave the safety of underground shelters and face a world that no longer resembles home. The setting moves across a battered Europe, where every decision carries weight and every journey feels uncertain. Rather than repeating the ticking-clock chaos of the original, Migration leans into endurance, exhaustion and the question of whether rebuilding is even possible. It’s a post-apocalyptic movie about movement, loss and the cost of starting over.
Release Date: March 20, 2026
Director: Phil Lord & Chris Miller
Stars: Ryan Gosling, Milana Vayntrub, Sandra Hüller
Based on Andy Weir’s best-selling novel, Project Hail Mary is shaping up to be one of the most talked-about space survival films of 2026. Ryan Gosling stars as Ryland Grace, an unlikely astronaut whose journey into space begins with confusion rather than heroics. Grace, a former junior high science teacher, wakes up alone on a spacecraft, cut off from Earth and missing key memories about how he got there. As pieces slowly fall into place, so does the scale of the problem he’s been sent to solve. The film blends real science with high-stakes isolation, balancing quiet moments with the pressure of a mission that affects the entire planet. Directed by Phil Lord and Chris Miller, Project Hail Mary promises tension, curiosity and a heavy dose of human vulnerability set against the vastness of space.
Release Date: March 27, 2026
Director: Ridley Scott
Stars: Jacob Elordi, Josh Brolin
The Dog Stars strips the apocalypse down to its bare essentials. Based on Peter Heller’s novel of the same name, the film features a screenplay by Mark L. Smith and Christopher Wilkinson, known for The Revenant and Ali. The setup of The Dog Stars is simple and bleak: a virus has erased most of humanity. What’s left is silence, abandoned airfields and roaming scavengers known as the “Reapers” who prey on the few survivors left behind.
Jacob Elordi plays Hig, a pilot living in isolation with his dog and a heavily armed companion. His days follow a strict routine, broken only by short flights in his aging Cessna. That fragile balance shatters when a distant radio signal breaks through the quiet. It’s the first real sign of life he has heard in years, and it draws him toward a journey that could change everything. Directed by Ridley Scott, the film focuses less on large-scale destruction and more on loneliness, hope and the risk of reaching out in a broken world. The result is a post-apocalyptic thriller that feels intimate, reflective and quietly tense.
Release Date: June 26, 2026
Director: Craig Gillespie
Stars: Milly Alcock, Jason Momoa, Matthias Schoenaerts
Supergirl: Woman of Tomorrow offers a very different take on the DC universe. This is a cosmic sci-fi story first, superhero film second. Kara Zor-El is older, tougher and shaped by memories of a world she lost. Unlike her cousin Superman, she remembers the destruction of Krypton clearly, and that history weighs heavily on her. The film follows Kara as she crosses paths with a young alien seeking justice, pulling her into a dangerous journey across distant worlds. Rather than focusing on Earth-saving spectacle, the story explores identity, grief and what heroism looks like far from home. With Milly Alcock stepping into the role, Supergirl 2026 aims to expand DC’s sci-fi side while giving the character emotional depth rarely seen on screen.
One reason science fiction movies stick with us is that they ask big questions in a way that feels personal. What happens when tech starts filling emotional gaps? What does survival look like when the world doesn’t bounce back? And how far would you go to save everyone you’ve ever known? If you’re looking for 2026 sci-fi movies that range from gritty to hopeful to unsettling, this lineup has you covered.