Researcher tending seedlings in a laboratory environment. PHOTO: FREEPIK
Bindwell is testing a simple idea: use AI to design smarter, more targeted pesticides built for today’s farming challenges.
Updated
November 14, 2025 10:48 PM
Researcher tending seedlings in a laboratory environment. PHOTO: FREEPIK
Bindwell, a San Francisco–based ag-tech startup using AI to design new pesticide molecules, has raised US$6 million in seed funding, co-led by General Catalyst and A Capital, with participation from SV Angel and Y Combinator founder Paul Graham. The round will help the company expand its lab in San Carlos, hire more technical talent and advance its first pesticide candidates toward validation.
Even as pesticide use has doubled over the last 30 years, farmers still lose up to 40% of global crops to pests and disease. The core issue is resistance: pests are adapting faster than the industry can update its tools. As a result, farmers often rely on larger amounts of the same outdated chemicals, even as they deliver diminishing returns.
Meanwhile, innovation in the agrochemical sector has slowed, leaving the industry struggling to keep up with rapidly evolving pests. This is the gap Bindwell is targeting. Instead of updating old chemicals, the company uses AI to find completely new compounds designed for today’s pests and farming conditions.
This vision is made even more striking by the people leading it. Bindwell was founded by 18-year-old Tyler Rose and 19-year-old Navvye Anand, who met at the Wolfram Summer Research Program in 2023. Both had deep ties to agriculture — Rose in China and Anand in India — witnessing up close how pest outbreaks and chemical dependence burdened farmers.
Filling the gap in today’s pesticide pipeline, Bindwell created an AI system that can design and evaluate new molecules long before they hit the lab. It starts with Foldwell, the company’s protein-structure model, which helps map the shapes of pest proteins so scientists know where a molecule should bind. Then comes PLAPT, which can scan through every known synthesized compound in just a few hours to see which ones might actually work. For biopesticides, they use APPT, a model tuned to spot protein-to-protein interactions and shown to outperform existing tools on industry benchmarks.
Bindwell isn’t selling AI tools. Instead, the company develops the molecules itself and licenses them to major agrochemical players. Owning the full discovery process lets the team bake in safety, selectivity and environmental considerations from day one. It also allows Bindwell to plug directly into the pipelines that produce commercial pesticides — just with a fundamentally different engine powering the science.
At present, the team is now testing its first AI-generated candidates in its San Carlos lab and is in early talks with established pesticide manufacturers about potential licensing deals. For Rose and Anand, the long-term vision is simple: create pest control that works without repeating the mistakes of the last half-century. As they put it, the goal is not to escalate chemical use but to design molecules that are more precise, less harmful and resilient against resistance from the start.
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Can AI companions really help with our mental health?
Updated
November 4, 2025 10:01 PM
A laptop with the text "MENTAL HEALTH" displayed. PHOTO: PEXELS
As technology continues to weave itself into the fabric of our daily lives, it’s starting to play an unexpected role: supporting our mental health. AI companions—digital entities designed to hold natural, empathetic conversations—are emerging as a new frontier in emotional care. Unlike chatbots of the past, these AI companions leverage advanced algorithms and emotional intelligence to provide personalized support, making them more than just tools. They are companions in every sense of the word—always available, always listening, and always ready to offer comfort. But can AI companions truly help us feel better, or are they just another tech trend? Let’s dive into how these digital allies are reshaping mental health care and what their growing presence means for our emotional well-being.
Loneliness is often called an epidemic, with millions of people worldwide feeling isolated or disconnected. While human relationships are irreplaceable, AI companions offer a consistent and accessible alternative to combat feelings of loneliness.
These companions don’t just respond—they engage. They remember your preferences, ask follow-up questions, and adapt their conversations to your needs. Imagine having someone to talk to at any time of day, about anything on your mind, without fear of judgment. AI companions may not replace a human friend, but they can provide a sense of presence and connection that can be profoundly comforting.
In a world where reaching out to others can sometimes feel daunting, AI companions offer a simple solution: they’re always there. This consistency can help people feel less alone, fostering a sense of connection in an increasingly disconnected world.
We all experience moments of stress, sadness, or doubt, and having someone to turn to during those times can make all the difference. AI companions are designed with emotional intelligence, enabling them to recognize and respond to your feelings in real time.
Through sentiment analysis and adaptive learning, these companions can detect when you’re feeling low and tailor their responses to provide comfort. Whether it’s offering words of encouragement, suggesting self-care activities, or simply listening, they provide a safe space to process emotions.
Unlike traditional apps that focus on tracking habits or delivering generic advice, AI companions meet you where you are emotionally. This personalized approach can help users feel truly supported, even in their most challenging moments.
For many of us, expressing our thoughts and emotions openly can feel like a risk. Fear of judgment, misunderstanding, or even burdening others often holds us back. AI companions offer an alternative: a completely private, judgment-free space to share whatever is on your mind.
Talking things out—whether it’s frustrations from the day or deeper personal struggles—can be incredibly therapeutic. And with AI companions, there’s no need to worry about being misunderstood or dismissed. You can let your guard down, explore your feelings, and reflect on your experiences with total freedom.
This safe space for self-expression can be especially valuable for those who struggle to open up to others. It’s not about replacing human relationships but about having an outlet that’s always available and entirely focused on you.
Self-doubt is a common barrier to personal growth, and many of us battle negative self-talk daily. AI companions are programmed to combat this by offering positive reinforcement and encouragement.
For example, if you express doubt about your abilities, an AI companion might respond with affirmations like, “You’ve accomplished so much already—don’t forget how capable you are.” Over time, these small but meaningful interactions can help shift your mindset, replacing self-criticism with self-compassion.
This ability to mirror supportive, affirming conversations can build confidence and foster a more positive self-image. It’s a subtle but powerful way AI companions can contribute to emotional well-being.
AI companions are more than just a tech trend; they represent a new way of thinking about mental health care. By offering companionship, emotional support, safe spaces for self-expression, and tools for mindfulness, they empower users to take control of their well-being.
While they may not replace traditional methods of care, AI companions are making mental health support more accessible, immediate, and personalized. They’re a reminder that sometimes, the smallest interactions—an encouraging word, a moment of mindfulness, or a listening ear—can have the biggest impact.
As we embrace this new era of technology, one thing is clear: AI companions are not just about convenience. They’re about connection, support, and the potential to make emotional care a part of everyday life. And in a world that often feels disconnected, that’s something worth celebrating.